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Secretions from the harderian gland, found in the orbit of some rodents and thought to be an accessory to the lachrymal gland in some species, inhibit aggression and appear to induce appeasement in blind mole-rats (Shanas & Terkel, Reference Shanas and Terkel1997)
Furthermore, the treatment of HIV-infected patients with S-adenosylmethionine, a precursor of homocysteine that is used in GSH synthesis, induced an increase of GSH levels in CSF [24]
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In a glucose-deprived tumor microenvironment (TME), which is generally seen when nutrients are depleted, high level of lactate is converted into pyruvates (LDH-catalyzed reverse reaction) and then cancer cells can utilize pyruvate for the TCA cycle through the action of pyruvate kinase [81]